导师风采
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段才闻
研究员
博士生导师
科室：转化所
专业：肿瘤学
国家卫健委儿童血液肿瘤重点实验室副主任，国家卫健委非人灵长类生育调剂技术评价重点实验室副主任（兼），儿科转化医学研究所血液肿瘤研究室副主任。中国病理生理学会实验血液学专业委员会青年委员
个人简介
段才闻，男，1979.12.17出生，博士学位，研究生学历，研究方向：骨髓微环境与血液疾病。国家卫健委儿童血液肿瘤重点实验室副主任，国家卫健委非人灵长类生育调剂技术评价重点实验室副主任（兼），儿科转化医学研究所血液肿瘤研究室副主任。中国病理生理学会实验血液学专业委员会青年委员。主持国家科技部重点研发计划（干细胞及转化研究）-青年科学家项目（首席科学家）和国家自然科学基金面上项目等多项国家及省部级课题。曾荣获上海市优秀博士学位论文（2015）、上海市卫生系统银蛇奖（2017）、上海市人才发展资金（2018）、中华医学科技二等奖（2018）和上海市教委“曙光学者”（2019）等荣誉和奖励。目前以第一作者和/或通讯作者在Cancer Cell、Leukemia和Blood等杂志发表论文20余篇，申请专利3项。
研究方向
骨髓微环境与血液疾病
招生信息
| 序号 | 专业 | 招生类型 | 招生人数 | 年份 |
| 1 | 肿瘤学 | 学术型博士 | 1 | 2022 |
| 2 | 肿瘤学 | 学术型硕士 | 1 | 2023 |
科研项目
（1）国家重点研发计划青年科学家项目，病理性骨髓微环境中造血干细胞的生物学行为及命运决定的规律研究，2016YFA0102000，2016-07至2021-06,578万，结题，主持。
（2）国家自然科学基金面上项目，骨髓血管微环境介导MLL-AF4型急性淋巴细胞白血病耐药复发的机制研究,82070158，2021-01至2024-12，64.8万，在研，主持。
（3）国家自然科学基金面上项目，骨髓微环境动态表达IGF2调控造血干细胞代谢适应的机制研究,81870082，2019-01至2022-12，68.4万，在研，主持。
（4）国家自然科学基金面上项目，炎性趋化因子介导骨髓微环境重塑在急淋发病中的作用及机制研究,81570121, 2016-01至2019-12, 72万，结题，主持。
（5）上海市优秀学术带头人项目（青年），骨髓血管微环境调控MLL-AF4型婴儿白血病治疗抵抗的机制研究，2021-07至2024-06，40万，在研，主持。
（6）上海市教委曙光计划项目，骨髓血管微环境代谢重塑在MLL-AF4型白血病耐药复发中的作用及机制研究，19SG14，2020-01至2022-12，15万，在研，主持。
研究成果
(1) Cai-Wen Duan#, Jun Shi#, Jing Chen#, Bo Wang#, Ye-Hua Yu, Xia Qin, Xiang-Cheng Zhou, Yi-Jun Cai, Zuo-Qing Li, Fang Zhang, Min-Zhi Yin, Ying Tao, Jian-Qing Mi, Lin-Heng Li, Tariq Enver*, Guo-Qiang Chen* and Deng-Li Hong*. Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy. Cancer Cell, 2014 Jun 16;25(6):778-93. DOI: 10.1016/j.ccr.2014.04.015
(2) Ya-Li Chen#, Chao Tang#, Meng-Yi Zhang#, Wen-Li Huang, Yan Xu, Hui-Ying Sun, Fan Yang, Li-Li Song, He Wang, Lili Mu, Ming-Hao Li, Wei-Wei Zheng, Yan Miao, Li-Xia Ding, Benshang Li, Shuhong Shen, Sheng-Li Liu, Hui Li, Zhong-Qun Zhu, Hui-Wen Chen, Zhong-Hua Tang, Jing Chen, Dengli Hong, Hong-Zhuan Chen*, Cai-wen Duan*, and Bin-Bing S Zhou*. Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia. Leukemia. 2019 Oct;33(10):2365-2378. DOI: 10.1038/s41375-019-0458-0
(3) Chao Tang, Ming-Hao Li, Ya-Li Chen, Hui-Ying Sun, Sheng-Li Liu, Wei-Wei Zheng, Meng-Yi Zhang, Hui Li, Wei Fu, Wen-Jun Zhang, Ai-Bin Liang, Zhong-Hua Tang, Deng-Li Hong, Bin-Bing S Zhou*, Cai-Wen Duan*. Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia. J Exp Clin Cancer Res. 2018 Aug 29;37(1):204. DOI: 10.1186/s13046-018-0859-3
(4) Wen-Li Huang#, Tuersunayi Abudureheman#, Jing Xia, Lei Chu, Hang Zhou, Wei-Wei Zheng, Neng Zhou, Rong-Yi Shi, Ming-Hao Li, Jian-Min Zhu, Kai Qing, Chao Ji, Kai-Wei Liang, Sa Guo*, Gang Yin* and Cai-Wen Duan*. CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism. Front. Cell Dev. Biol., 04 March 2021 | https://doi.org/10.3389/fcell.2021.641271
(5) Tuersunayi Abudureheman#, Jing Xia#, Ming-Hao Li#, Hang Zhou, Wei-Wei Zheng, Neng Zhou, Rong-Yi Shi, Jianmin Zhu, Li-Ting Yang, Li Chen, Liang Zheng, Kai Xue, Kai Qing* and Cai-Wen Duan*. CDK7 inhibitor THZ1 induces the cell apoptosis of B-cell acute lymphocytic leukemia by perturbing cellular metabolism. Front. Oncol. 2021. doi: 10.3389/fonc.2021.663360
(6) Dabin Tang, Shengli Liu, Huiying Sun, Xia Qin, Neng Zhou, Weiwei Zheng, Mengyi Zhang, Hang Zhou, Abudureheman Tuersunayi, Caiwen Duan*, Jing Chen*. All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia. Br J Haematol. 2020 Dec;191(5):906-919. doi: 10.1111/bjh.16871.
(7) Meng-Yi Zhang#, Sheng-Li Liu#, Wen-Li Huang, Da-Bin Tang, Wei-Wei Zheng, Neng Zhou, Hang Zhou, Tuersunayi Abudureheman, Zhong-Hua Tang, Bin-Bing S Zhou*, Cai-Wen Duan*. Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis. Med Sci Monit. 2020 Apr 8;26:e923411. DOI: 10.12659/MSM.923411
(8) Hui Li, Chao Tang, Xiaowei Zhu, Weiwei Zhang, Mieradilijiang Abudupataer, Suling Ding, Caiwen Duan*, Xiangdong Yang*, Junbo Ge*. Histamine Deficiency Facilitates Coronary Microthrombosis After Myocardial Infarction by Increasing Neutrophil-Platelet Interactions. J Cell Mol Med. 2020 Mar;24(6):3504-3520. DOI: 10.1111/jcmm.15037
(9) Sheng-Li Liu#, Yan-Man Zhou#, Da-Bin Tang, Neng Zhou, Wei-Wei Zheng, Zhong-Hua Tang, Cai-Wen Duan*, Jing Chen*. Rapamycin ameliorates immune-mediated aplastic anemia by inhibiting the proliferation and metabolism of T cells. Biochem Biophys Res Commun. 2019 Oct 15;518(2):212-218. DOI: 10.1016/j.bbrc.2019.08.034
(10) Sheng-Li Liu#, Yan-Man Zhou#, Da-Bin Tang, Neng Zhou, Wei-Wei Zheng, Zhong-Hua Tang, Cai-Wen Duan, Liang Zheng*, Jing Chen*. LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2019 Oct 29;519(1):1-7. DOI: 10.1016/j.bbrc.2019.08.122
(11) Dan F#, Zhou X#, Li Z#, Li ZQ#, Duan C#, Liu T, Zhang F, Huang Y, Zhang Y, Gao F, Guo Y, Gupta R, Chen G, Enver T, Tang J*, Hong D*. Stem Cell Programs are Retained in Human Leukemic Lymphoblasts. Oncogene. 2015 Apr 16;34(16):2083-93. DOI: 10.1038/onc.2014.148.
(12) Xie-Na Cao#, Yuan Kong#, Yang Song, Min-Min Shi, Hong-Yan Zhao, Qi Wen, Zhong-Shi Lyu, Cai-Wen Duan, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang*. Impaired bone marrow endothelial progenitor cells are involved in the pathogenesis of acute graft-versus-host disease after allotransplant. Br J Haematol. 2018 Sep;182(6):870-886. DOI: 10.1111/bjh.15456
(13) Hong-Yan Zhao, Zhong-Shi Lyu, Cai-Wen Duan, Yang Song, Ting-Ting Han, Xiao-Dong Mo, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yuan Kong*. An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation. Br J Haematol. 2018 Sep;182(5):679-692. DOI: 10.1111/bjh.15452
