个人简介

张马忠，男，2003年于上海第二医科大学麻醉学专业博士毕业，师从杭燕南教授。长期致力于临床麻醉相关的临床和科研工作。目前担任上海市知联会理事；中华麻醉学会小儿麻醉学组副组长；中国心胸血管麻醉学会理事，小儿麻醉学副主委；中国药理学会麻醉药理专业委员会常委；中国高等教育学会医学教育专业委员会麻醉学教育研究会理事；国际麻醉与复苏杂志常务编委；上海医学杂志编委；临床麻醉学杂志编委等。曾在匹兹堡大学医学中心（UPMC）和辛辛那提儿童医院医学中心（CCHMC）学习器官移植麻醉、TEE的应用，研修生理药代药效学建模以及发育药理学相关知识；从事临床麻醉工作20多年，主要研究方向为发育麻醉药理学、发育与疼痛。获得国家自然科学基金2项，卫生局重点薄弱学科1项，发表SCI论文30余篇，主编主译专著4部。

研究方向

主要研究方向为发育麻醉药理学、发育与疼痛

张马忠

Zhangmazhong@scmc.com.cn

招生信息

张马忠

Zhangmazhong@scmc.com.cn

科研项目

1.上海市“科技创新行动计划” 自然科学基金项目，20ZR1434600， LncRNA Silc1调节Elavl4/GAP43诱发青春期迟发神经病理性疼痛机制的研究，2020-07至2023-06，20万元，在研，主持.

2.国家自然科学基金委员会重点项目，81730031，全麻药诱导新生动物神经细胞选择性凋亡的机制及对婴幼儿认知功能影响的临床多中心研究，2018-01至2022-12，290万元，在研，主要参与人.

3.国家自然科学基金委员会面上项目，81270414，以异丙酚作为工具药基于单心室循环建立混杂生理药代药效学模型，2013-01至2016-12，70万元，结题，主持.

4.上海市卫生计生系统，2015ZB0106，重要薄弱学科建设小儿麻醉学专业，2016-01至2018-12，150元，结题，主持.

张马忠

Zhangmazhong@scmc.com.cn

研究成果

1. Liu C, Liu J, Zhou L, He H, Zhang Y, Cai S, Yuan C, Luo T, Zheng J, Yu T, Zhang M. Lateral Habenula Glutamatergic Neurons Modulate Isoflurane Anesthesia in Mice. Front Mol Neurosci. 2021 Mar 4;14:628996. doi: 10.3389/fnmol.2021.628996. eCollection 2021.

2. Lei Wu,Qiaoru Hou,Jie Bai,Jianwei Zhang,Liping Sun,Ruizhen Tan,Mazhong Zhang,Jijian Zheng. Modified Lung Ultrasound Examinations in Assessment and Monitoring of Positive End-Expiratory Pressure-Induced Lung Reaeration in Young Children With Congenital Heart Disease Under General Anesthesia. Pediatr Crit Care Med. 2019 May;20(5):442-449. doi: 10.1097/PCC.00000000000 01865.

3. Jing Chang,Yang Shen,Yue Huang,Ying Sun,Mei-Hua Cai,Jing Niu,Li-Ming Zhang,Ji-Jian Zheng,Ma-Zhong Zhang. Population Pharmacokinetic Modeling of Remifentanil in Infants with Unrepaired Tetralogy of Fallot. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):53-62. doi: 10.1007/s13318-018-0489-3.

4. PP Liu, Y Sun, C Wu, WH Xu, RD Zhang, JJ Zheng, Y Huang, YQ Chen, MZ Zhang, JZ Wu. The effectiveness of transport in a toy car for reducing preoperative anxiety in preschool children: a randomised controlled prospective trial. Br J Anaesth. 2018 Aug; 121(2):438-444. doi: 10.1016/j.bja.2018.02.067.

5. Xingrui Gong,Yongmei Chen,Jing Chang,Yue Huang,Meihau Cai,Mazhong Zhang. Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury. J Neuroinflammation. 2018 Sep 12;15(1):262. doi: 10.1186/s12974-018-1301-7.

6. Yuan J, Cao S, Huang Y, Zhang Y, Xie P, Zhang Y, Fu B, Zhang T, Song G, Yu T, Zhang M. Altered Spontaneous Brain Activity in Patients With Idiopathic Trigeminal Neuralgia: A Resting-state Functional MRI Study. Clin J Pain. 2018 Jul;34(7):600-609. doi: 10.1097/AJP.0000000000000578.

7. Zhiyu Chen,Xiaolu Shen,La Huang,Hai Wu,Mazhong Zhang. Membrane potential synchrony of neurons in anterior cingulate cortex plays a pivotal role in generation of neuropathic pain. Sci Rep. 2018 Jan 26;8(1):1691. doi: 10.1038/s41598-018-20080-2.

8. Jing Chang, Yuefeng Xia, Karla Wasserloos, Meihong Deng, Kory J Blose, David A Vorp, Heth R Turnquist, Timothy R Billiar, Bruce A Pitt, Ma-Zhong Zhang, Li-Ming Zhang. Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells. PLoS One . 2017 Sep 12;12(9):e0184770. doi: 10.1371/journal.pone.0184770. eCollection 2017.

9. Bao Fu,Tian Yu,Jie Yuan,Xingrui Gong,Mazhong Zhang. Noradrenergic transmission in the central medial thalamic nucleus modulates the electroencephalographic activity and emergence from propofol anesthesia in rats. J Neurochem. 2017 Mar;140(6):862-873. doi: 10.1111/jnc.13939. Epub 2017 Jan 26.

10. Xingrui Gong,Yongmei Chen,Bao Fu,Jing Jiang,Mazhong Zhang. Infant nerve injury induces delayed microglial polarization to the M1 phenotype, and exercise reduces delayed neuropathic pain by modulating microglial activity. Neuroscience. 2017 May 4;349:76-86. doi: 10.1016/ j.neuroscience.2017.02.051.

11. Yong-Xiang Wang,Xiao-Fang Mao,Teng-Fei Li,Nian Gong,Ma-Zhong Zhang. Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptor activation and norepinephrine reuptake inhibition. Sci Rep. 2017 Feb 23;7:43137. doi: 10.1038/srep43137.

12. Yang Shen,Mei-Hua Cai,Wei Ji,Jie Bai,Yue Huang,Ying Sun,Lin Lin,Jing Niu,Ma-Zhong Zhang. Unrepaired Tetralogy of Fallot-related Pathophysiologic Changes Reduce Systemic Clearance of Etomidate in Children. Anesth Analg. 2016 Sep;123(3):722-30. doi: 10.1213/ANE.000000000000 1477.

13. Xingrui Gong,Jing Jiang,Mazhong Zhang. Exercise preconditioning reduces neonatal incision surgery-induced enhanced hyperalgesia via inhibition of P38 mitogen-activated protein kinase and IL-1β, TNF-α release. Int J Dev Neurosci Actions Search in PubMed Search in NLM Catalog Add to Search . 2016 Aug;52:46-54. doi: 10.1016/j.ijdevneu.2016.05.008.

14. Li-Hong Jin,Yan-Yan Song,Yang Shen,Wei Ji,Ma-Zhong Zhang. Post-Exposure Exercise Fails to Ameliorate Memory Impairment Induced by Propofol and Ketamine in Developing Rats. Med Sci Monit Actions Search in PubMed Search in NLM Catalog Add to Search . 2016 Mar 30;22:1038-46. doi: 10.12659/msm.895443.