郑吉建 主任医师

博士生导师兼任专业学位导师
科室：麻醉科
专业：麻醉学

麻醉科主任，麻醉与危重医学教研室主任。现任中国心胸血管麻醉学会非心脏手术麻醉分会和小儿麻醉分会常委；中国医药教育协会临床用药评价专业委员会理事兼儿童用药评价分会委员；上海市麻醉专科委员会小儿学组副组长；上海中西医结合麻醉与镇痛学会常委；上海市麻醉质控专家委员会委员。

个人简介

郑吉建，男，1966年 09月，医学博士，主任医师，博士研究生导师，麻醉科主任，麻醉与危重医学教研室主任。现任中国心胸血管麻醉学会非心脏手术麻醉分会和小儿麻醉分会常委；中国医药教育协会临床用药评价专业委员会理事兼儿童用药评价分会委员；上海市麻醉专科委员会小儿学组副组长；上海中西医结合麻醉与镇痛学会常委；上海市麻醉质控专家委员会委员；《中华麻醉学杂志》编委等。长期从事麻醉与危重医学临床、教学与科研工作，积累了丰富的经验。在国家自然基金和上海市科委等资助下，长期从事神经发育电生理及药理学研究，尤其是发育过程中的神经保护以及可视化技术在小儿围术期的应用等工作。作为第一作者或通讯作者在Nature Neuroscience、Neuron、Anesthesia & Analgesia，European Journal of Anaesthesiology等杂志发表SCI论文余30篇。部分工作受到Science STKE、Nature Neuroscience、Trends in Neuroscience 和 Faculty1000 等杂志的高度评价。

研究方向

神经发育电生理及药理学研究，尤其是发育过程中的神经保护以及可视化技术在小儿围术期的应用等工作

郑吉建

zhengjijian626@sina.com

招生信息

序号	专业	招生类型	招生人数	年份
1	麻醉学	学术型硕士	1	2022
2	麻醉学	学术型博士	1	2023

郑吉建

zhengjijian626@sina.com

科研项目

1. 国家自然科学基金委员会，81771218，自发性节律性神经网络电活动协同有序转换调控Zn2+-MMP2/9-BDNF轴介导全身麻醉药神经发育毒性易感窗口期研究，2018-01至2021-12，54万元，在研，主持.

2. 国家自然科学基金委员会，81271263，兴奋性与抑制性神经网络整合在全身麻醉诱导发育早期中枢神经毒性中的作用及机制，2013-01至2016-12，65万元，结题，主持.

3.上海市科委自然科学基金，21ZR1441100，circRanbp9-microRNAs-RanBP9表达上调参与介导全身麻醉药神经发育毒性的易感窗口期研究，2021-07至2024-06，20万元，在研，主持.

4.上海市科委医学引导类，16411967500，复杂性先天性心脏病患儿围术期动态肺功能超声评估体系的建立与评价，2016-07至2019-06，20万元，结题，主持.

郑吉建

zhengjijian626@sina.com

研究成果

1. Kan Zhang,Lei Wu,Kana Lin,Mazhong Zhang,Weiguang Li,Xiaoping Tong,Jijian Zheng. Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development. Exp Neurol Actions Search in PubMed Search in NLM Catalog Add to Search . 2021 Jun;340:113659. doi: 10.1016/j.expneurol.2021.113659. Epub 2021 Feb 26.

2. Sen Zhang, Ruidong Zhang, Meihua Cai, Kan Zhang, Mazhong Zhang, Jijian Zheng. Intranasal dexmedetomidine premedication in children with recent upper respiratory tract infection undergoing interventional cardiac catheterisation: A randomised controlled trial. Eur J Anaesthesiol Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Feb;37(2):85-90. doi: 10.1097/EJA.0000000000001097.

3. Bo Li,Ruidong Zhang,Yue Huang,Kan Zhang,Chun Yin Wat,Jie Bai,Mazhong Zhang,Jijian Zheng. Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children's hospitals in China: a questionnaire survey from China. BMC Health Serv Res Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Jan 8;20(1):28. doi: 10.1186/s12913-019-4885-4.

4. Liping Sun,Lei Wu,Kan Zhang,Ruizhen Tan,Jie Bai,Mazhong Zhang,Jijian Zheng. Lung ultrasound evaluation of incremental PEEP recruitment maneuver in children undergoing cardiac surgery. Pediatr Pulmonol Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 May;55(5):1273-1281. doi: 10.1002/ppul.24720.

5. Kan Zhang,Siyuan Wang,Mengqi Li,Chi Wu,Liping Sun,Sen Zhang,Jie Bai,Mazhong Zhang,Jijian Zheng. Anesthesia timing for children undergoing therapeutic cardiac catheterization after upper respiratory infection: a prospective observational study. Minerva Anestesiol Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Aug;86(8):835-843. doi: 10.23736/S0375-9393.20.14293-7.

6. Lei Wu,Kan Zhang,Liping Sun,Jie Bai,Mazhong Zhang,Jijian Zheng. Laminin degradation by matrix metalloproteinase 9 promotes ketamine-induced neuronal apoptosis in the early developing rat retina. CNS Neurosci Ther Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Jun 20;26(10):1058-1068. doi: 10.1111/cns.13428.

7. Kan Zhang,Siyuan Wang,Lei Wu,Yun'an Song,Meihua Cai,Mazhong Zhang,Jijian Zheng. Newborn infant parasympathetic evaluation (NIPE) as a predictor of hemodynamic response in children younger than 2 years under general anesthesia: an observational pilot study. BMC Anesthesiol Actions Search in PubMed Search in NLM Catalog Add to Search . 2019 Jun 11;19(1):98. doi: 10.1186/s12871-019-0774-y.

8. Lei Wu,Siyuan Wang,Yanting Wang,Kan Zhang,Jie Bai,Jijian Zheng. Prediction of Hemodynamic Reactivity by Electroencephalographically Derived Pain Threshold Index in Children Undergoing General Anesthesia: A Prospective Observational Study. J Pain Res Actions Search in PubMed Search in NLM Catalog Add to Search . 2019 Dec 3;12:3245-3255. doi: 10.2147/JPR.S231596. eCollection 2019.

9. Lei Wu,Qiaoru Hou,Jie Bai,Jianwei Zhang,Liping Sun,Ruizhen Tan,Mazhong Zhang,Jijian Zheng. Modified Lung Ultrasound Examinations in Assessment and Monitoring of Positive End-Expiratory Pressure-Induced Lung Reaeration in Young Children With Congenital Heart Disease Under General Anesthesia. Pediatr Crit Care Med Actions Search in PubMed Search in NLM Catalog Add to Search . 2019 May;20(5):442-449. doi: 10.1097/PCC.0000000000001865.

10. Lingqi Gao,Junde Han,Jie Bai,Jing Dong,Sen Zhang,Mazhong Zhang,Jijian Zheng. Nicotinic Acetylcholine Receptors are Associated with Ketamine-induced Neuronal Apoptosis in the Developing Rat Retina. Neuroscience Actions Search in PubMed Search in NLM Catalog Add to Search . 2018 Apr 15;376:1-12. doi: 10.1016/j.neuroscience.2018.01.057.

11. Lei Wu,Qiaoru Hou,Yingying Lu,Jie Bai,Liping Sun,Yue Huang,Mazhong Zhang,Jijian Zheng. Feasibility of lung ultrasound to assess pulmonary overflow in congenital heart disease children. Pediatr Pulmonol Actions Search in PubMed Search in NLM Catalog Add to Search . 2018 Nov;53(11):1525-1532. doi: 10.1002/ppul.24169.

12. S Zhang, S Ding,M Cai,J Bai,M Zhang,Y Huang,J Zheng. Impact of upper respiratory tract infections on perioperative outcomes of children undergoing therapeutic cardiac catheterization. Acta Anaesthesiol Scand Actions Search in PubMed Search in NLM Catalog Add to Search . 2018 Aug;62(7):915-923. doi: 10.1111/aas.13113.

13. Zifeng Xu,Tao Xu,Puwen Zhao,Rui Ma,Mazhong Zhang,Jijian Zheng. Differential Roles of the Right and Left Toe Perfusion Index in Predicting the Incidence of Postspinal Hypotension During Cesarean Delivery. Anesth Analg Actions Search in PubMed Search in NLM Catalog Add to Search . 2017 Nov;125(5):1560-1566. doi: 10.1213/ANE.0000000000002393.

14. Junde Han,Lingqi Gao,Jing Dong,Yingtian Wang,Mazhong Zhang,Jijian Zheng. Dopamine attenuates ethanol-induced neuroapoptosis in the developing rat retina via the cAMP/PKA pathway. Mol Med Rep Actions Search in PubMed Search in NLM Catalog Add to Search . 2017 Aug;16(2):1982-1990. doi: 10.3892/mmr.2017.6823.

15. Junde Han,Lingqi Gao,Jing Dong,Jie Bai,Mazhong Zhang,Jijian Zheng. The expression profile of developmental stage-dependent circular RNA in the immature rat retina. Mol Vis Actions Search in PubMed Search in NLM Catalog Add to Search . 2017 Jul 20;23:457-469. eCollection 2017.

16. Jing Dong,Lingqi Gao,Junde Han,Junjie Zhang,Jijian Zheng. Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity. Mol Neurobiol Actions Search in PubMed Search in NLM Catalog Add to Search . 2017 Jul;54(5):3407-3417. doi: 10.1007/s12035-016-9914-2.